Oral Health Complications of X-Linked Hypophosphatemia
By Sarah Gianetti, RDH, BS, JoAnn Gurenlian, RDH, MS, PhD, AFAAOM
X-linked hypophosphatemia (XLH) is a genetic disorder caused by a mutation in the PHEX gene located on the X chromosome.1 Affecting approximately one in 20,000 births, it is the most common form of hereditary rickets.2 Symptoms range from hypophosphatemia without bone-related manifestations to severe symptoms that may impact activities. Most cases occur early in childhood, while some cases may affect adults. Clinically, XLH is often misdiagnosed or missed altogether.1 In addition to systemic findings, XLH poses risk for oral complications.3–5 All healthcare professionals, including oral health providers, should be aware of its multifaceted characteristics. This paper will describe the nature of this disease and the role of dental professionals in the prevention and treatment of oral complications.
* References can be found in the original article via the link below.
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