The Importance of Articaine in Dental Anesthesia

By Arthur C. DiMarco, DMD; and Kathy Bassett, RDH, MEd

Articaine was approved for use in the United States by the Food and Drug Administration (FDA) in 2000 as a 4% formulation with 1:100,000 epinephrine. In 2006, 4% articaine, 1:200,000 epinephrine was approved. More than two decades later, articaine is second only to lidocaine in worldwide use. As the first hybrid local anesthetic (LA) with both ester and amide properties, articaine’s developers emphasized dentistry’s requirement for a profound and durable LA with relativity rapid detoxification.

* References can be found in the original article via the link below.
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